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News & Updates
Stem cells help sex workers in Rehabilitation:
50 sex workers got a new life after being treated for VIRGINITY RESTORATION (VAGINOPLASTY/TIGHTNESS OF VAGINA) by Non-invasive procedure with their own adipose tissue derived cells- a joint effort by mother cell and NGO’s since the publication of last report...Know More

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Patient with Severe Brain Damage due to Thrombosis shows remarkable improvement:
Disabled 31 years old female because of Cerebral Venous Sinus Thrombosis for three years shows great signs of improvement. She was blinded, could not smell and had severe persisting headaches and could not walk properly due to incordination in my leg...Know More

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Ballad with Stem cells:
A portugese man nearly blind improves significantly after treatment with his own stem cells. the patient needed couple of boosters injections after initial treatment ...Know More

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The first successful noninvasive stem cell therapy for traumatic brain injury
A Man , suffering from altered sensorium, with complete visual loss, severe cognitive dysfunction and lack of movement in limbs For the past one and half year year regained full consciousness, reasonable memory, communication abilities and purposive movements in limbs ...Know More (a)
Know More (b)

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Upcoming training course in Stem Cell Research in Delhi & Chennai:
Mother Cell is holding a 2-day weekend Training Course in Delhi & Chennai.The training will cover Autologous, Bonemarrow & Adipose Stem Cell Technology: Extraction, isolation, Activation & Administration...Read More

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Stem-cells help American see again:
New Delhi, DNA: Seven years after he lost his sight following acute illness, it was no less than a miracle for 62-year-old Carl Stevens when he was able to catch a glimpse of the Taj Mahal after treatment...Read More

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Spinal cord injury is not incurable:
Translated version from Scandinavian news (Iceland) The omental transposition with good stabilization in contusion injuries has yielded very good results in all experimental treatments done so far: Dr Himanshu Bansal....Read More

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Tomorrow's Technology Today: Express Health Care:
Results with adipose tissue derived stem cell were encouraging in spinal cord injury. Bone marrow has a different cocktail of stem cells, and abundant quantity of growth factors which are necessary for cell proliferation and differentiation....Read More

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Stem cells can change your life: India Today
Thirty year old patient with complete spinal injury got restoration of bladder control soon six months after stem cell treatment. He feels a new life and has fathered a child now....Read More

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High on stem cell cocktail –boy fights cerebral palsy, New Indian Express:
A 5 yr old boy tried his own mother(stem cells) and is back on feet so much so that he is attending normal school....Read More

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Stem cells help youth get eyesight Deccan chronicle:
Stem cell therapy shows light of day to US medico; Times of India:
Doctors in the US had said that this 22 yr old had no chance of regain vision. When I reach US tomorrow, I will first go to my ophthalmologist and tell her than in can see you....Read More

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Stem cell cure for Incurable Blindness, Hindustan Times:
The Visual evoked potential tests showed that Mr Patil has got back ninety percent of his vision...Read More

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Omental transposition: institute of spinal cord injury Iceland:
Dr Himanshu Bansal (India) and colleagues have incorporated Goldsmith’s omental transposition ideas into their growing therapeutic armamentarium for SCI. In acute setting it is recommended only for pure contusion injuries....Read More

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International Data Base on Spinal cord Injury treatment modalities:
Stem cell technique of Dr bansal recognised by forums working for spinal injured: The concentrate maintains the fundamental nature of stem cells as well as has abundant growth factors. No physical or chemical harassment of these specialized cells is done....Read More

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Interview Dr bansal on possible treatment approaches on spinal cord injury:
Read More

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Ballad with Stem cells:
A portugese man nearly blind improves significantly after treatment with his own stem cells. the patient needed couple of boosters injections after initial treatment ...Know More
Preclinical   results suggest that bone marrow cells may provide a source of stem cells with a potential for migration into inflamed CNS and differentiate into cells expressing neuronal and glial cell markers b islets, hepatocytes etc. Several published studies that have documented the positive clinical effect of delivering bone marrow mononuclear cells. Our own results of pilot human studies are encouraging   Based on these available data, we are currently offering a safe and similar therapeutic approach in a small group of patients with various neurodegenerative diseases, hepatic and pancreatic disorders.

Probable mechanism:

In sub acute phase it is possible to prevent further ongoing damage to nerve along with Rejuvenation of normal axons back to function by natural growth factors injected along with stem cells. Stem cells also help by secreting these factors after implantation. Bone marrow derived MSCs have enormous remyelination potential which is a phenomenon of covering nude but intact axons. Once covered these axons start working. Some of these cells also turn into helper cells so that non- functional but intact axons start functioning. In long term sitting few of these stem cells may become neurons and form connections too.In chronic phase though all is not lost but scarred and degenerated nerve becomes a greater challenge.

Current Status

Autologous stem cells have advantage in terms of immune compatibility and ethical issues.

Two major lines of investigation have emerged –one advocating stem cell enrichment only and the other doing expansion with or without differentiating these endogenous stem cells.

Culture of stem cells though increases the number but there are concerns of induction of mutations, change the behaviour of cells etc.

Enrichment has the advantage of fresh cells along with cocktail of numerous different types of supportive cells and growth factors necessary for promoting cell growth.

Though stem-cell therapy could fundamentally change medicine, almost all treatments being developed were still in an experimental stage or under clinical trial, except for bone marrow transplants.

Clinical stem cell application should be done as a trial in those conditions where scientific evidence in literature is available. It should be carried as clinical trial in few patients (max 20) in which sound preclinical data exists .once the results are encouraging. It should be published followed by a placebo controlled clinical trial on more number of patients ... If the individual or centre wishes can apply for patent for future monetary gains.  Any centre claiming of doing hundreds of cases in a particular disease is nonsense.

Stem cell research and therapy should not be hyped but presented as a possible hope.

Many hospitals and centers have overstated their stem-cell treatments with very bold claims.

Don’t be carried away with Testimonials as it can be generated Fake. Understand the Science and if willing kindly participate in it as an experiment.

The field needs time to grow and mature, before stem cells can be turned into clinical and other applications. It will happen, but not right away."

Patient Education

Allogenic cells (not from Patient’s own tissue) should not come to even clinical trial without preclinical and phase 1 study.

Ficoll- ficoll plus. Lymphoprep, ficoll premium) for mesenchymal stem cell isolation from bone marrow aspirate is not recommended for any clinical use.  

    Cells leave there biological environment.

    Leads to loss of  not only Mesenchymal cells but also VSELS

    Does not keeps the charcterstics of these stem cells intact.

    Though may not  kill these cells but greatly influences their functional charcterstics.

    Not  rich  in neurotrophic growth factors neseccary for stem cells to home at lesion.

    No studies or data available for safey of ficoll  --biological  effects n cells cell aging damage in the genome (genotoxic ), changes in chromatin structure . Possibility of mutations and late tumor formation.

    Further it has been shown earlier that CFU (a way of assessment of functional efficacy) is even poorer then native bone marrow.

Avoid use of Cryo preserved cells as much as possible as on thawing viability is lost up to 25 %. There death further increases during transportation. The biological behavior also deteriorates. Ideal is fresh expanded cells directly from Lab.

Route of administration should be as Direct as possible. (Intralesional, feeding artery of the organ involved)

On administering Intravenous- majority of these cells will not reach target, so needs high dose and multiple administration are needed.

In nutshell a patient should understand

  • quantity of cells being injected.
  • Type of cells:  Stem cells are identified by markers. E.g. haematopoietic (CD34 +ve) or mesenchymal (Cd 34 –Ve, CD 105 +ve)

It would be very appropriate for a centre to provide sample of the cells for cross verification.